ImmunocCellular’s Licensing Deal with U Penn Next Step on Prosperity’s Path

Shepherding a biotechnology company down the regulatory pathway is full of value-driving milestones; some just generally not as widely acknowledged as others.  Of course, the major accomplishments, such as moving from one clinical phase to the next, deservedly send share prices higher, but there are many other steps that more subtly signal corporation advancements and help boost the odds of the end-goal of FDA approval that are crucial on the path to biotech prosperity.  Immunotherapy, treatments that elicit or amplify an immune response to allow a person’s body to combat disease, is an extremely promising and rapidly growing industry with companies like Celldex Therapeutics (NASDAQ:CLDX), Oncothyreon (NASDAQ:ONTY) and ImmunoCellular Therapeutics (OTCBB:IMUC) making strides to lead the heralded technology into the mainstream of healthcare.

The beauty for investors is that the immunotherapy sector has some lesser-known companies that have unparalleled headroom for share appreciation as the junior biotechs emerge as industry leaders.  On Tuesday, ImmunoCellular announced that it has entered into an agreement with the University of Pennsylvania under which University of Pennsylvania has granted the Company an exclusive, worldwide license for a patent pending technology for the production of high-activity dendritic cells (DCs). The license covers the application of this technology to the development of therapeutics for all indications except breast cancer and ductal carcinoma in situ (a type of malignant tumor generally found in the ducts of a gland, but has not metastasized).

While the license will cover a broad array of other possibilities for ImmunoCellular, today it is important for ICT-107, IMUC’s lead DC-based cancer vaccine candidate for the treatment of glioblastoma multiforme, a common and deadly form of brain cancer.  ImmunoCellular is in the second stage of clinical trials using ICT-107 as an indication for glioblastoma after phase I trials showed the IMUC product to well-outperform today’s standard means of care with 40% of the ICT-107 treated patients being disease-free in three years compared to a meager 6% of those treated by standard care.

Developed by Brian J. Czerniecki, M.D., Ph.D., co-director of University of Pennsylvania’s Rena Rowan Breast Cancer Center and Surgical Director of the immunotherapy program at the Abramson Cancer Center, the technology enables the development of DCs designed to trigger powerful and targeted immune responses to specific cancer antigens.

In the natural human immune system, DCs are responsible for capturing, processing and presenting antigens to T-cells, which in turn target the antigens and destroy them. A key juncture in the process of immunity, the DC’s conversion from antigen-capturing to antigen-presenting mode, known as maturation, relies on the production of special messenger cells known as cytokines. Dr. Czerniecki’s technology produces DCs that express very high levels of the cytokines interleukin (IL) -12 and –IP-10, which have been shown to play a key role in initiating T-cell response.

Manish Singh, Ph.D., IMUC’s president and CEO, commented, “This licensing agreement represents an expansion of our intellectual property surrounding the technology underlying our lead product candidate, ICT-107. In addition to contributing to the powerful immune responses to ICT-107 we have observed to date, this technology also enables the manufacture of multiple vaccine shots from a single production run, allowing us to significantly reduce the cost of manufacturing the vaccine. As we continue advancing our ongoing Phase II trial in glioblastoma, we are confident that will continue to realize the benefits of the enhanced efficacy and efficiency of this innovative dendritic-cell production method.”

ImmunoCellular (IMUC)

Biotech investors are well-aware of the cyclic patterns of pharmaceutical companies and that speculative companies moving through clinical trials can yield tremendous upswings in share value.  IMUC’s new licensing agreement is another building block in this growth cycle.  Interest in IMUC is clearly escalating as volume and share price have dramatically increased in the last six weeks as enrollment for phase II research is happening.  It’s a pivotal point in development to validate their products and adds credence to the chances of one day garnering FDA approval – or even accelerated approval – by offering a superior product to a disease with a great unmet need for better life-saving treatments.  Yet, at only $1.80 a share, the potential upside to IMUC is unprecedented compared to its much higher-priced peers.

ImmunoCellular Therapeutics (IMUC) Stock Quote and News:

Disclaimer: Neither nor its officers, directors, partners, employees or anyone involved in the publication of the website or newsletters (“us” or “we”) is a registered investment adviser or licensed broker-dealer in any jurisdiction whatsoever. Further, we are not qualified to provide any investment advice and we make no recommendation to purchase or sell any securities. The prior article is published as information only for our readers. is a third party publisher of news and research. Our site does not make recommendations, but offers information portals to research news, articles, stock lists and recent research. Nothing on our site should be construed as an offer or solicitation to buy or sell products or securities. This site is sometimes compensated by featured companies, news submissions and online advertising. Viper Enterprises, LLC (parent company of OTC Showcase) has r received no compensation for this article from and owns no shares of the aforementioned company(ies). Please read and fully understand our entire disclaimer at


Add your comment

Commenting is allowed only for registered users.

Other articlesgo to homepage

Stocks Mixed on Monday

Stocks Mixed on Monday(0)

The Dow Jones industrial average topped 16,000 for the first time ever Monday, while the S&P 500 briefly surpassed 1,800. The Dow retreated from the 16,000 level, but still gained 14.32 points from Friday”s all-time high close, to 15,976. The S&P 500 index dipped 6.65 points to 1,791.53. The NASDAQ fell 36.90 points to 3,949.07

Catalyst Pharmaceutical Partners Stock Chart Analysis Video

Catalyst Pharmaceutical Partners Stock Chart Analysis Video(0)

The Catalyst Pharmaceutical Partners (NASDAQ: CPRX) stock chart formed a piercing line reversal pattern on Wednesday and Thursday that was confirmed with a sharp move upwards on Friday. Technical traders will be watching support around the 200 day moving average at $1.25 on any pullback, but for the time being, the chart looks to be

EnteroMedics Stock Chart Analysis Video

EnteroMedics Stock Chart Analysis Video(0)

The EnteroMedics (NASDAQ:ETRM) chart has been making higher highs and higher lows since forming a double bottom early in the year. The chart is holding over the 50-day moving average and inching higher each day as it tries to gain momentum to make the next leg up in the channel. EnteroMedics is a medical device

NXT-ID Authentication Using Face and Voice Recognition

NXT-ID Authentication Using Face and Voice Recognition(0)

There’s a Wocket in My Pocket! may soon not just be a sentence from the mouths of children after reading the rhyming book by Dr. Seuss. There was plenty of made-up ridiculousness in the iconic book, such as a bofa on the sofa, but there is nothing fictitious about the Wocket, a next-generation payment and

Dow Not Tired of Making New Record Highs

Dow Not Tired of Making New Record Highs(0)

The Dow Jones Industrials will have to wait till at least next week to mount the lofty heights of 16,000 points, but both the Dow and the S&P did end the day at record highs. The Dow Jones Industrials was up 85.48 points from yesterday”s all-time high, to close at 15,961.70 The S&P 500 index

read more

Stay Informed

Receive the OTCS Newsletter *


* required

Dana-Farber to Host Cellceutix Trials

Cellceutix Corporation (CTIX)
Cellceutix Corporation has filed its Investigational New Drug application with the FDA. Dana-Farber and Beth Israel Deaconess Medical Center will be hosting the clinical trials for Kevetrin, Cellceutix's novel cancer drug. Read more news and get a stock quote.

Diabetes Rate Growing Exponentially

According to the International Diabetes Federation, more than 500 million people will be diagnosed with diabetes in the next two decades, a more than 50 percent increase from today. Technologies are available presently to help manage the frequency, complications and costs associated with diabetes. Read the complete article to learn more.

Contacts and information

Have an opinion or news that you want to share?

Social networks

Most popular categories

© 2011 Viper Enterprises, LLC. All rights reserved.