
Cellceutix has been in the news and attracting investor attention lately as developments with Kevetrin as a novel indication for a variety of drug-resistant cancers nears clinical trials after producing strong pre-clinical data.
Leo Ehrlich, CEO of Cellceutix, tells BioMedReports in an exclusive interview that p53 is a key component in regulating the cell cycle.
“In more than half of all cancers, the p53 has lost all or a portion of its function which allows cancer cells to run rampant,” explains Ehrlich. “Researchers have known about the p53 correlation to carcinomas, but have yet been able to come-up with a solution to restore the function of p53. There was a class of drugs called ‘Nutlins’ a few years ago that believed to hold promise, but proved to be genotoxic — meaning that the drug damaged the host’s DNA — so that quickly was realized as not a viable option. Kevetrin has proven to this point to restore p53 back to a normal status so it can do its job as master regulator and see to it that the cancer cells are destroyed without damaging any DNA.”

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